Berberis vulgaris alleviates Levodopa-induced dyskinesia in male mice
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منابع مشابه
Compound Formula Rehmannia alleviates levodopa-induced dyskinesia in Parkinson's disease
Compound Formula Rehmannia has been shown to be clinically effective in treating Parkinson's disease and levodopa-induced dyskinesia; however, the mechanisms remain unclear. In this study, we established a model of Parkinson's disease dyskinesia in rats, and treated these animals with Compound Formula Rehmannia. Compound Formula Rehmannia inhibited the increase in mRNA expression of N-methyl-D-...
متن کاملExercise attenuates levodopa-induced dyskinesia in 6-hydroxydopamine-lesioned mice.
L-DOPA alleviates the motor symptoms of Parkinson's disease, but its long-term use is associated with undesirable dyskinesia. We now tested whether exercise can attenuate this L-DOPA-induced dyskinesia (LID). We tested the effects of exercise on LID in 6-hydroxydopamine hydrochloride-hemiparkinsonian mice. Animals were treated with L-DOPA/benserazide (25/12.5 mg/kg, i.p.) without and with possi...
متن کاملLevodopa-induced dyskinesia and thalamotomy.
Levodopa-induced dyskinesia of the limbs in thirteen cases of Parkinsonism, which was choreic, ballistic or dystonic in type, was alleviated almost completely by stereotaxic surgery using a microelectrode technique for the ventralis oralis anterior and posterior nuclei of the thalamus, but much less by the ventralis intermedius nucleus. Control of levodopa-induced dyskinesias by thalamic lesion...
متن کاملLevodopa-induced dyskinesia and striatal signaling pathways.
P arkinson’s disease (PD) is the most common movement disorder, affecting 2% of individuals over age 60 (1). The cardinal clinical features of PD are resting tremor, rigidity, bradykinesia, and postural instability, which are often accompanied by autonomic, cognitive, and emotional disturbances. The neuropathological hallmark of PD is the degeneration of dopaminergic neurons in the substantia n...
متن کاملLevodopa-Induced Dyskinesia: Medical and Surgical Management
Although levodopa therapy remains the most effective symptomatic treatment for PD, its usefulness may be limited by these motor complications, which result in deterioration in quality of life. Levodopa-induced dyskinesia (LID) is characterized by a variety of hyperkinetic movements. Although chorea and dystonia are the most common manifestations of LID, stereotypies, tics, myoclonus, or ballism...
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ژورنال
عنوان ژورنال: Herba Polonica
سال: 2018
ISSN: 2449-8343
DOI: 10.2478/hepo-2018-0023